IKKα Antibody
货号：
2682S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2682S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | IKKα Antibody detects endogenous levels of total IKKα protein. The antibody does not cross-react with IKKβ or IKKγ. |
| 使用方法 | WB(1:1000)
IP (1:100) |
性能| 供应商 | CST |
| 背景 | The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins (1-3). Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB (3-7). The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex, whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit (8,9). Activation of IKK depends upon phosphorylation; Ser177 and Ser181 in the activation loop of IKKβ (serine 176 and 180 in IKKα) are the specific sites whose phosphorylation causes conformational changes resulting in kinase activation (10-13). |
| 存放说明 | -20C |
| 计算分子量 | 85 |
参考图片Western blot analysis of extracts from NIH/3T3, HeLa and PC12 cells, using IKKα Antibody.Western免疫印迹。用IKKα Antibody研究NIH/3T3, HeLa 和PC12 细胞的细胞提取液。 |
