IGFBP3 Antibody
货号：
13216S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 13216S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | IGFBP3 Antibody recognizes endogenous levels of total IGFBP3 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Insulin-like growth factor (IGF) signaling plays a major role in regulating the proliferation and metabolism of normal and malignant cells (1). Insulin-like growth factor-binding proteins (IGFBPs) play an integral role in modifying IGF actions in a wide variety of cell types. The six IGFBP family members share a high affinity for IGF binding and are structurally related, but are encoded by distinct genes (1). IGF binding proteins can exert stimulatory or inhibitory effects by controlling IGF availability through high affinity binding of IGF at the carboxy-terminal domain (2,3). IGFBP3 is the most abundant serum IGF binding protein and the main mediator for IGF-I bioactivities. IGFBP3 also binds IGF-II, insulin, and other cellular and extracellular components to regulate cell growth, development, and apoptosis through both IGF-dependent and IGF-independent mechanisms (4-8). Research studies describe correlations between increased IGF-I levels and reduced levels of IGFBP3 with increased risks of developing cancer, including breast, colon, lung, and prostate cancer (2). |
| 存放说明 | -20C |
| 计算分子量 | 40 |
参考图片Western blot analysis of concentrated conditioned media from serum-starved A-431 cells, untreated (-) or treated with Human Insulin-like Growth Factor I (hIGF-I) #8917 (100 nM, 12 hr; +), using IGFBP3 Antibody. 使用IGFBP3对未处理(-)或Human Insulin-like Growth Factor I (hIGF-I) #8917 (100 nM, 12 hr; +)处理的血清饥饿的A-431细胞培养基浓缩液进行western blot分析。 |
