| 货号 | 3922S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P |
| 目标/特异性 | IGFBP-2 Antibody detects endogenous levels of total IGFBP-2 protein. It does not cross-react with other IGFBP family members. |
| 使用方法 | WB(1:1000) IP (1:50) IHC-P (1:25) |
| 供应商 | CST |
| 背景 | Insulin-like growth factor-binding proteins (IGFBPs) play an integral role in modifying insulin-like growth factor (IGF) actions in a wide variety of cell types. This family contains six members that are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction (1-3). IGFBP-2 is the second most abundant IGFBP in the circulation and is present in various other biological fluids and tissues of many vertebrate species. Serum IGFBP-2 levels are elevated in conditions such as shock, fasting, hypoxemia or after traumata, suggesting complex regulation of IGFBP-2 expression (4). IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to a potential involvement of IGFBP-2 in tumorigenesis (5). |
| 存放说明 | -20C |
| 计算分子量 | 35 |
Western blot analysis of human serum and extracts from various cell lines, using IGFBP-2 Antibody. Wetern blot检测人血清和多种细胞提取物，所用抗体为IGFBP-2 Antibody。 | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, showing cytoplasmic localization, using IGFBP-2 Antibody. 免疫组织化学检测石蜡包埋的人乳腺癌组织，显示与胞质的共定位，所用抗体为IGFBP-2 Antibody |
