IDH1 Antibody
货号：
3997S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3997S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | IDH1 Antibody detects endogenous levels of total IDH1 protein. The antibody does not cross react with IDH2. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | IDH1 is one of three isocitrate dehydrogenases that catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). These enzymes exist in two distinct subclasses that utilize either NAD or NADP+ respectively, as an electron acceptor (1). IDH1 is the NADP+-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. IDH2 and 3 are mitochodrial enzymes that also function in the Krebs cycle. IDH1 is inactivated by phosphorylation at Ser113 and contains a clasp-like domain wherein both polypeptide chains in the dimer interlock (2,3). IDH1 is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma (4). IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway (5). |
| 存放说明 | -20C |
| 计算分子量 | 46 |
参考图片Western blot analysis of extracts from HepG2 and NIH/3T3 cells using IDH1 Antibody. Wetern blot检测HepG2 和NIH/3T3细胞提取物，所用抗体为IDH1 Antibody。 |
