HtrA2 Antibody
货号：
2176S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2176S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | HtrA2 Antibody detects endogenous levels of the mature form of HtrA2. This antibody is expected to also recognize the unprocessed form of HtrA2. The unprocessed form is detected in cells overexpressing HtrA2. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | HtrA2 (High temperature requirement protein A2)/Omi is a serine protease with homology to the E. coli HtrA protein (DegP) and is thought to be involved in apoptosis and stress induced degradation of misfolded proteins (1). While HtrA2 was orignally identified to be present in either the nucleus (1) or endoplasmic reticulum (2), subsequent studies have since shown it to be localized in mitochondria and released during apoptosis (3-7). HtrA2 is produced as a 50 kDa zymogen that is cleaved to generate a 36 kDa mature protein that exposes an amino terminal motif (AVPS) resembling that of the IAP inhibitor Smac/Diablo (3-7). Like Smac, interaction between HtrA2 and IAP family members such as XIAP antagonizes their inhibition of caspase activity and protection from apoptosis (3-7). Interestingly, HtrA2 knock-out mice did not show show signs of reduced apoptosis, but rather had a loss of neurons in the striatum and a Parkinsons-like phenotype, suggesting that HtrA2 might have a neuroprotective function (9-11). This activity is associated with the protease activity of HtrA2 (9). Furthermore, loss of function mutations in the HtrA2 gene have been found in Parkinsons disease (12). |
| 存放说明 | -20C |
| 计算分子量 | 36 |
参考图片Western blot analysis of extracts from HT1080, Raji and BaF3 cell lines, using HtrA2 Antibody. Western blot分析HT1080、Raji和BaF3细胞提取物，使用抗体为HtrA2 Antibody。 |
