Heregulin Antibody
货号：
2573S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2573S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Heregulin Antibody detects endogenous levels of total heregulin proteins. The antibody does not cross-react with other family members. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Heregulin (HRG), also called neuregulin (NRG1), neu differentiation factor (NDF) or glial growth factor-2 (GGF-2), is a soluble growth factor synthesized as a transmembrane precursor molecule. Metalloproteinases and other proteases catalyze the cleavage of its extracellular domain which is then released and functions as a ligand for ErbB3 and ErbB4 receptor tyrosine kinase. The signaling pathways of HRG-ErbB3/ErbB4 are involved in regulation of cell proliferation, differentiation, invasion, and survival of both normal and malignant tissues (1,2). Abnormality of HRG-ErbB signaling leads to development of a variety of human diseases.
HRG family has four isoforms including HRG-1, -2, -3 and -4, which are derived from alternative exon splicing. Moreover, they showed various tissue expression and biological activities (3). |
| 存放说明 | -20C |
| 计算分子量 | 105 |
参考图片Western blot analysis of extracts from various cell lines using Heregulin Antibody. 使用Heregulin抗体对多种细胞提取物进行western blot分析。 |
