| 货号 | 3227S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | GβL Antibody detects endogenous levels of total GβL protein. |
| 使用方法 | WB(1:1000) IHC-P (1:50) |
| 供应商 | CST |
| 背景 | Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian Target of Rapamycin (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL, and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, and rictor (1). GβL associates with the kinase domain of mTOR and stimulates mTOR kinase activity (2). A reduction in GβL expression has been shown to decrease in vivo phosphorylation of S6K1 (2). |
| 存放说明 | -20C |
| 计算分子量 | 37 |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using GβL Antibody in the presence of control peptide (left) or antigen specific peptide (right). | |
免疫组织化学方法检测石蜡包埋的人乳腺癌组织，对照肽段处理（左图）和抗原特异性肽处理（右图）；使用的抗体是GβL Antibody。 | |
