| 货号 | 2816S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IF-IC |
| 目标/特异性 | Grp75 Antibody detects endogenous levels of total Grp75 protein. |
| 使用方法 | WB(1:1000) IF-IC (1:25) |
| 供应商 | CST |
| 背景 | Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat-inducible (1,2). This protein is essential for transporting many mitochondrial proteins from the cytoplasm to mitochondria (3). Grp75 inactivates the tumor suppressor p53 (4). Studies found that Grp75 is overexpressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation (5). Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts (6). |
| 存放说明 | -20C |
| 计算分子量 | 75 |
Western blot analysis of extracts from various cell types using Grp75 Antibody. 对多个细胞系使用Grp75 Antibody进行Western blot分析。 | |
Confocal immunofluorescent analysis of MCF-7 cells using Grp75 Antibody (green) showing colocalization with mitochondria that have been labeled with MitoTracker® Red CMXRos (red). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye). 对MCF-7细胞使用Grp75 Antibody（绿色）进行共聚焦免疫荧光分析显示与MitoTracker® Red CMXRos（红色）标记的线粒体共定位。蓝色伪彩=DRAQ5®(荧光DNA染料)。 |
