GRB2 Antibody
货号：
3972S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3972S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Growth factor receptor-binding protein 2 (GRB2) is a adaptor protein that is involved in RTK signal transduction. The SH2 domain of GRB2 binds to tyrosine phosphorylated proteins such as EGFR, IRS-1, Shc and Gab1 (1). The SH3 domain of GRB2 associates with Sos, which stimulates the GTP binding activity of Ras, leading to the activation of the MAP kinase and other signaling pathways. Phosphorylation of tyrosine 209 of GRB2 by Bcr-Abl and EGFR abolishes its association with Sos and negatively regulates downstream signaling (2). |
| 存放说明 | -20C |
| 计算分子量 | 25 |
参考图片Western blot analysis of extracts from HeLa, A431, HEK293, Ramos, NIH/3T3, C6, COS, CHO and BAEC cells, using GRB2 Antibody.western blot方法检测细胞提取物：HeLa, A431, HEK293, Ramos, NIH/3T3, C6, COS, CHO和BAEC细胞。使用的抗体是GRB2 Antibody。 |
