GIT2 Antibody
货号：
6953S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 6953S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | GIT2 Antibody recognizes endogenous levels of total GIT2 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | G protein-coupled receptor (GPCR) kinase interacting proteins 1 and 2 (GIT1 and GIT2) are highly conserved, ubiquitous scaffold proteins involved in localized signaling to help regulate focal contact assembly and cytoskeletal dynamics. GIT proteins contain multiple interaction domains that allow interaction with small GTPases (including ARF, Rac, and cdc42), kinases (such as PAK and MEK), the Rho family GEF Pix, and the focal adhesion protein paxillin (reviewed in 1). GIT1 and GIT2 share many of the same properties but with at least ten distinct, tissue-specific splice variants. GIT2 has been shown to play an important role in inhibiting focal adhesion turnover and membrane protrusion (2,3). Focal adhesion localization and paxillin binding of GIT2 is regulated through phosphorylation at one or more tyrosine sites (Tyr286, Tyr392, Tyr592) by FAK and/or Src (4,5,reviewed in 6). Once at the focal adhesion, GIT2 is thought to play a key role in cell polarity and migration, making it a protein of interest in the investigation of oncogenic signaling pathways (3,5,7). |
| 存放说明 | -20C |
| 计算分子量 | 85 |
参考图片Western blot analysis of extracts from various cell lines using GIT2 Antibody.使用GIT2抗体对多种细胞提取物进行western blot分析。 |
