FXR2 Antibody
货号：
4247S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4247S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | FXR2 Antibody detects endogenous levels of total FXR2 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Fragile X syndrome is a genetic disorder characterized by a spectrum of physical and behavioral features and is a frequent form of inherited mental retardation (1). X-linked FMRP (FMR-1) and its two autosomal homologs, FXR1 and FXR2, are polyribosome-associated RNA-binding proteins that are involved in the pathogenesis of fragile X syndrome (1-3). Each of the fragile X proteins can self-associate as well as form heteromers with the other two related proteins (3). FMRP can act as a translation regulator and is a component of RNAi effector complexes (RISC), suggesting a role in gene silencing (4). The Drosophila homolog of FMRP (dFMRP) associates with Argonaute 2 (Ago2) and Dicer and can coimmunoprecipitate with miRNA and siRNA (5). These results suggest that fragile X syndrome is related to abnormal translation caused by defects in RNAi-related pathways. In addition, FMRP, FXR1 and FXR2 are components of stress granules (SG) and have been implicated in the translational regulation of mRNAs (6). |
| 存放说明 | -20C |
| 计算分子量 | 95 |
参考图片Western blot analysis of HeLa, 293 and A-204 cells using FXR2 Antibody. 使用FXR2 Antibody，免疫印迹（Western Blotting）分析HeLa、293 和A-204细胞系提取物。 |
