FTH1 Antibody
货号：
3998S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3998S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | FTH1 Antibody detects endogenous levels of total FTH1 protein. Nonspecific bands are seen above 80 kDa. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Ferritin (FTH) is an ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and bioavailable form (1). The assembled ferritin molecule, often referred to as a nanocage, can store up to 4,500 atoms of iron (2, 3). It forms a holoenzyme of ~450 kDa, consisting of 24 subunits made up of two types of polypeptide chains, ferritin heavy chain and ferritin light chain, each having unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III) (4). In addition to iron buffering, heavy chain ferritin also enhances thymidine biosynthesis (5). Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia. The level of serum ferritin is markedly elevated in inflammation, malignancy, and iron overload disorders (6). Defects in ferritin proteins are also associated with several neurodegenerative diseases (7). |
| 存放说明 | -20C |
| 计算分子量 | 21 |
参考图片Western blot analysis of extracts from HT-29 and HeLa cells using FTH1 Antibody. Wetern blot检测 HT-29和HeLa 胞提取物，所用抗体为FTH1 Antibody。 |
