Frizzled5 Antibody
货号：
3795S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3795S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Frizzled5 Antibody detects transfected levels of total frizzled5 protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Frizzled (Fzd) belongs to the seven transmembrane-spanning G-protein-coupled receptor (GPCR) superfamily (1). Fzds have a large extracellular N-terminal region containing a cysteine-rich domain (CRD), which is involved in binding to Wnt proteins (1,2). The intracellular C-terminus binds to the PDZ domain of Dvl proteins, a major signaling component downstream of Fzd (3). Wnt proteins bind to Fzd and the co-receptors LRP5 or LPR6, and activate Wnt/β-catenin pathway through inhibiting phosphorylation of β-catenin by GSK3-β (4,5). In addition to this canonical Wnt/β-catenin pathway, some Wnt proteins can also activate the Fzd/Ca2+ pathway and Fzd/PCP (planar cell polarity) pathway (6,7). The mammalian Fzd subfamily has 10 members (Fzd1 to Fzd10) and they may mediate signaling through different pathways (8). Some Fzds can also bind to other secreted proteins, like Norrin and R-Spondin (9-11). |
| 存放说明 | -20C |
| 计算分子量 | 50-65 |
参考图片Western blot analysis of extracts from COS cells, mock transfected or transfected with human Frizzled5, using Frizzled5 Antibody.使用Frizzled5 抗体对未转染或转染了人Frizzled5 的COS细胞提取物进行进行western blot分析。 |
