FMRP (G468) Antibody
货号：
4524S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4524S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | FMRP (G468) Antibody detects endogenous levels of total FMRP protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Fragile X syndrome, a frequent cause of inherited mental retardation, often results from expansion of the CGG trinucleotide repeat in the gene that encodes the fragile X mental retardation protein (FMRP) (1). FMRP (also known as FMR1) and its two autosomal homologs (FXR1 and FXR2) all bind RNA and play a role in the pathogenesis of fragile X syndrome (1-3). Each of these related proteins can associate with one another as well as form homodimers (3). FMRP can act as a translation regulator and is a component of RNAi effector complexes (RISC), suggesting a role in gene silencing (4). In Drosophila, dFMRP associates with Argonaute 2 (Ago2) and Dicer and coimmunoprecipitates with miRNA and siRNA. These results suggest that fragile X syndrome is related to abnormal translation caused by a defect in RNAi-related pathways (5). In addition, FMRP, FXR1, and FXR2 are components of stress granules (SG) and have been implicated in the translational regulation of mRNAs (6). |
| 存放说明 | -20C |
| 计算分子量 | 80 |
参考图片Western blot analysis of extracts from various cell lines using FMRP (G468) Antibody. 使用FMRP (G468) Antibody，免疫印迹（Western Blotting）分析不同细胞系提取物。 |
