| 货号 | 8245S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | FKBP5 Antibody recognizes endogenous levels of total FKBP5 protein. This antibody does not cross-react with FKBP4 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to the FKBP family of immunophilins (1). FKBP family proteins contain FK domains and TPR (tetratricopeptide repeat) domains. The FK domains are responsible for their PPIase (peptidylprolyl isomerase) acitivity and their ability to bind FK506 and Rapamycin (2,3). The C terminal TPR domains are involved in protein-protein interactions. The C terminal TPR domain of FKBP5 mediates binding to HSP90 complexes (4) and glucocorticoid, androgen and progesterone receptors, which underlies its regulatory role in steroid hormone receptor function (5). FKBP5 also binds to IKKα and is involved in NF-κB signaling (6,7). Recently, FKBP5 was identified as a negative regulator of Akt (8); it promotes Akt - PHLPP interaction and enhances dephosphorylation of Akt. |
| 存放说明 | -20C |
| 计算分子量 | 51 |
Western blot analysis of extracts from HeLa and SH-SY5Y cells using FKBP5 Antibody. Western blot 分析HeLa 和SH-SY5Y细胞提取物，所用抗体为FKBP5 Antibody。 |
