FKBP4 Antibody
货号：
11826S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11826S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | FKBP4 Antibody recognizes endogenous levels of total FKBP4 protein. This antibody does not cross-react with other FKBP proteins. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | FKBP4 (also known as FKBP52) is a member of the immunophilin protein family. FKBP4 does not demonstrate appreciable immunosuppressant activity typical of this family, despite its ability to bind the immunosuppressants FK506 and rapamycin (1,2). While FKBP4 plays an important role in immunoregulatory gene expression in B and T lymphocytes, its role in regulating steroid hormone receptor signaling and cytoskeletal dynamics is garnering significant interest. FKBP4 contains two petidyl-prolyl cis-trans isomerase (PPIase) domains, the first of which is implicated in steroid receptor signaling while the second interacts with tubulin and other cytoskeletal components. The maturation of cytoplasmic steroid hormone receptors into a functional conformation requires multiple chaperone and co-chaperone components, including HSP90, p23, and FKBP4 (3,4). FKBP4 interacts with HSP90 to facilitate the folding of androgen, glucocorticoid, and progesterone steroid hormone receptors. Indeed, the functionality of these receptors is impaired in the absence of FKBP4, and research studies have found that null mice demonstrate signs of androgen insensitivity syndrome (5). In addition, FKBP4, which is expressed at high levels in the brain, interacts with hyperphosphorylated Tau and antagonizes Taus ability to promote microtubule polymerization (6). FKBP4 can also suppress amyloid β toxicity in Drosophila by processing APP (Alzheimers Amyloid Precursor Protein) to unfold aggregates (7). |
| 存放说明 | -20C |
| 计算分子量 | 56 |
参考图片Western blot analysis of extracts from various cell lines using FKBP4 Antibody. Western blot方法检测多种细胞系的提取物，使用的抗体为FKBP4 Antibody。 |
