Filamin A Antibody
货号：
4762S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4762S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Filamin A Antibody detects endogenous levels of total filamin A protein. This antibody may cross-react with filamin B and C. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Filamins are a family of dimeric actin binding proteins that function as structural components of cell adhesion sites. They also serve as a scaffold for subcellular targeting of signaling molecules (1). The actin binding domain (alpha-actinin domain) is located at the very amino-terminus, followed by as many as 24 tandem repeats of about 96 residues, and the dimerization domain is located at the carboxy-terminal end of th protein. In addition to actin filaments, filamins associate with other structural and signaling molecules such as beta-integrins, Rho/Rac/Cdc42, PKC, and insulin receptor, primarily through their carboxy-terminal half (1-3). Filamin A, the most abundant, and filamin B, less abundant, are widely expressed isoforms, while filamin C is predominantly expressed in muscle (1). Serine 2152 of filamin A is phosphorylated by PAK1, and this phosphorylation is required for PAK1-mediated actin cytoskeleton reorganization (4). |
| 存放说明 | -20C |
| 计算分子量 | 280 |
参考图片Western blot analysis of extracts from HeLa, NIH/3T3, C6 and COS cells, using Filamin A Antibody. 使用Filamin A Antibody，免疫印迹（Western Blot）分析HeLa、NIH/3T3、C6和COS细胞中Filamin A蛋白水平。 |
