FGF Receptor 1 Antibody
货号：
3472S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3472S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | FGF Receptor 1 Antibody detects transfected levels of FGF receptor 1. It does not cross-react with other FGF receptor family members. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3, and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCγ (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 120, 145 |
参考图片Western blot analysis of extracts from COS cells transfected with the indicated amounts of human FGF receptor 1, using FGF Receptor 1 Antibody.Western blot法检测转染了一定量的人FGFR1的COS细胞的裂解液，使用的抗体为FGF Receptor 1 Antibody。 |
