| 货号 | 2736S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Fes Antibody detects endogenous levels of Fes proteins. This antibody does not cross-react with other proteins. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Fes/Fps and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases (1,2). Fps and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains (3). Fes/Fps was originally identified as an oncogene from avian (Fps) and feline (Fes) retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. Mutations may activate the Fps kinase and thereby contribute to cancer (4). However, recent data strongly suggests that the c-Fes protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer (5). |
| 存放说明 | -20C |
| 计算分子量 | 93 |
Flow cytometric analysis of Jurkat cells, using Fes Antibody (blue) compared to a nonspecific negative control antibody (red). 与非特异阴性control antibody (红色)比较，使用Fes Antibody (蓝色)标记，流式细胞仪分析Jurkat细胞。 | |
Western blot analysis of HEL and UT-7 cell lysates, using Fes Antibody. 使用Fes Antibody，免疫印迹（Western Blot）分析HEL和UT-7细胞中Fes蛋白水平。 |
