FEN-1 Antibody
货号:
2746S 基本售价:
3360.0 元 规格:
-
产品信息
概述货号 | 2746S |
反应种属 | Human/Mouse/Rat/Monkey |
来源宿主 | Rabbit |
应用 | W |
使用方法 | WB(1:1000) |
性能供应商 | CST |
背景 | Flap endonuclease-1 (FEN-1) is a structure-specific nuclease with multiple functions in DNA processing pathways (1,2). The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers (3). FEN-1 is also required for non-homologous end joining of double stranded DNA breaks in long patch base excision repair (4,5). The multi-functional activities of FEN-1 are regulated by various mechanisms, including protein partner interactions (6,7), post-translational modifications (8,9), and subcellular re-localization in response to cell cycle or DNA damage (10).Flap内切核酸酶1(FEN-1)是是一个结构特异的核酸酶,在DNA处理通路中具有多种功能(1,2)。 FEN-1的复制和DNA修复活性对真核细胞的基因组稳定性至关重要。通过与增殖细胞核抗原(PCNA)相互作用,FEN-1能够通过去除RNA-DNA引物来帮助协调冈崎片段成熟(3)。 FEN-1也为长补丁碱基切除修复中的双链DNA断裂的非同源末端连接所需(4,5)。 FEN-1的多功能活性受各种机制调控,包括蛋白质伴侣相互作用(6,7),翻译后修饰(8,9),以及响应细胞周期或DNA损伤的亚细胞定位(10)。 |
存放说明 | -20C |
计算分子量 | 45 |
参考图片Western blot analysis of extracts from Jurkat and HeLa cells using FEN-1 Antibody.Western blot方法检测Jurkat和Hela细胞提取物,使用的抗体为FEN-1 Antibody。 |