Fatty Acid Synthase Antibody
货号：
3189S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3189S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Fatty Acid Synthase Antibody detects endogenous levels of total fatty acid synthase protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Fatty acid synthase (FAS) catalyzes the synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA. FAS is active as a homodimer with seven different catalytic activities and produces lipids in the liver for export to metabolically active tissues or storage in adipose tissue. In most other human tissues, FAS is minimally expressed since they rely on circulating fatty acids for new structural lipid synthesis (1).
More recently, increased expression of FAS has emerged as a phenotype common to most human carcinomas. In breast cancer, immunohistochemical staining showed that the levels of FAS are directly related to the size of breast tumors (2). Studies also showed that FAS is highly expressed in lung and prostate cancers and that FAS expression is an indicator of poor prognosis in breast and prostate cancer (3-5). Furthermore, inhibition of FAS is selectively cytotoxic to human cancer cells (5). Thus, increased interest has focused on FAS as a potential target for the diagnosis and treatment of cancer as well as the metabolic syndrome (6,7). |
| 存放说明 | -20C |
| 计算分子量 | 273 |
参考图片Western blot analysis of extracts from various cell lines, using Fatty Acid Synthase Antibody. 对多个细胞系使用Fatty Acid Synthase Antibody抗体进行Western blot分析。 |
