| 货号 | 6907S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | FAIM Antibody recognizes endogenous levels of total FAIM protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 背景 | FAIM (Fas apoptosis inhibitory molecule) was identified as a protein that was inducibly expressed in B lymphocytes resistant to Fas-mediated apoptosis (1). Expression of FAIM inhibits receptor-mediated apoptosis in B cells as well as other cell types (1-3). FAIM is expressed in germinal center B cells, is positively regulated by IRF-4, and is also capable of inducing IRF-4 expression in a feed-forward mechanism (4). FAIM also regulates T cell receptor-mediated apoptosis by modulating Akt activation and Nur77 expression (2). Knockout mice for FAIM show an increased sensitivity to Fas-mediated apoptosis within B and T cells as well as hepatocytes (5). An alternatively spliced form of FAIM, termed FAIM-L, is found predominantly in the brain (6). In the nervous system, the originally identified FAIM does not appear to play a role in apoptosis, but rather can promote neurite outgrowth through the activation of Erk and NF-κB pathways (7). In contrast, FAIM-L does inhibit neuronal cell death triggered by death receptors (3). |
| 存放说明 | -20C |
| 计算分子量 | 19 |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with human FAIM (+), using FAIM Antibody. Western blot方法检测293T细胞提取物：空质粒（-）或人FAIM(+)转染；使用抗体为 FAIM Antibody。 | |
Western blot analysis of extracts from various cell lines using FAIM Antibody. Western blot 检测多种细胞系提取物，使用抗体为 FAIM Antibody。 |
