FAF1 Antibody
货号：
4932S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4932S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | FAF1 Antibody detects endogenous levels of FAF1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | FAF1 was originally identified though yeast two-hybrid screening, interacting with the cytoplasmic domain of Fas, a member of the TNF receptor superfamily that plays a critical role in in apoptosis during development and immune function (1). FAF1 is widely expressed with highest expression observed in testis, skeletal muscle and heart (2). FAF1 potentiates Fas-mediated apoptosis and may induce apoptosis without Fas stimulation in some cell types. It does not contain typical death motifs, but rather has two amino-terminal domains with structural homology to ubiquitin. While the precise role of FAF1 during apoptosis is still unclear, it has been observed to be one of the components of the death-inducing signaling complex (DISC) during Fas-mediated apoptosis and can bind to caspase-8 and FADD (3). FAF1 has also been shown to suppress the activation of the NF-kappaB transcription factor (4). |
| 存放说明 | -20C |
| 计算分子量 | 74 to 80 |
参考图片Western blot analysis of extracts from THP1 and C6 cells, using FAF1 Antibody. Western blot 检测THP1和C6细胞提取物，使用抗体为FAF1 Antibody。 |
