Erk5 Antibody
货号：
3372S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3372S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | ERK5 (Mitogen-activated protein kinase 7, Big mitogen-activated protein kinase 1) is a member of the MAPK superfamily implicated in the regulation numerous cellular processes including proliferation, differentiation and survival (1,5-7). Like other MAPK family members, ERK5 contains a canonical activation loop TEY motif (Thr218/Tyr220) which is specifically phosphorylated by MAP2K5 (MEK5) in a growth factor-dependent, Ras-independent mechanism (2-4). For example, EGF stimulation promotes ERK5 phosphorylation which induces its traslocation to the nucleus where it phosphorylates MEF2C and other transcriptional targets (2,3). ERK5 is also activated in response to granulocyte colony-stimulating factor (G-CSF) in hematopoetic progenitor cells where is promotes survival and proliferation (4). In neuronal cells, ERK5 is required for NGF-induced neurite outgrowth neuronal homeostatis and survival (11,12). ERK5 is thought to play a role in blood vessel integrity via maintainence of endothelial cell migration and barrier function (8-10). Although broadly expressed, mice lacking erk5 display numerous cardiac defects, suggesting ERK5 plays a critical role in vascular development and homeostasis (1,5). |
| 存放说明 | -20C |
| 计算分子量 | 115 |
参考图片Western blot analysis of extracts from HeLa cells, untreated or sorbitol-treated and NIH/3T3 cells, untreated or PDGF-treated, using Erk5 Antibody.Western blot方法检测细胞提取物：未经处理的和山梨醇处理的HeLa细胞，未经处理的和PDGF处理的NIH/3T3细胞，使用的抗体是Erk5 Antibody. |
