Erk3 Antibody
货号：
4067S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4067S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Erk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region (1). However, Erk3 is distinguished from other MAP kinases in that it lacks the conserved TXY motif in its activation loop, possessing instead an SEG motif (1,2). Phosphorylation at Ser189 in the SEG motif has been reported (2,3). With limited information about its upstream kinases and downstream substrates, the significance of this phosphorylation remains to be elucidated (3,4). Erk3 is an inherently unstable protein, rapidly degraded through amino-terminal ubiquitination and proteasome degradation (3,5). A site-specific cleavage, depending on a short stretch of acidic residues of Erk3, might regulate its translocation from the Golgi/ERGIC to the nucleus during the cell cycle (6). Accumulating evidence suggests that Erk3 is involved in cell differentiation (1,3,6). |
| 存放说明 | -20C |
| 计算分子量 | 105 |
参考图片Western blot analysis of extracts from A431, MCF7, HeLa, C6, NIH/3T3 and C2C12 cells, using Erk3 Antibody.Western blot方法检测细胞提取物：A431, MCF7, HeLa, C6, NIH/3T3 和 C2C12细胞，使用的抗体是Erk3 Antibody。 |
Flow cytometric analysis of untreated A431 cells, using Erk3 Antibody (blue) compared to a nonspecific negative control antibody (red).Flow Cytometry方法检测细胞提取物：未经处理A431细胞，使用的抗体是Erk3 Antibody (蓝色)，红色表示非特异性阴性对照抗体。 |
