ERC1 (P85) Antibody
货号：
2884S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2884S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | ERC1 (P85) Antibody detects endogenous levels of ERC1 protein. Both α and β isoforms of ERC1 are detected. |
| 使用方法 | WB(1:1000)
IP (1:100) |
性能| 供应商 | CST |
| 背景 | ERC1, an acronym named for previous protein names ELKS (1), RAB6IP2 (2) and CAST (3), is a RIM-binding protein that plays a role in neurotransmitter release and general membrane trafficking in other cell types (2-5). Interaction with the GTP-binding protein Rab6 suggests that it contributes to membrane traffic at the Golgi (2). In addition to its association with membrane trafficking, ERC1 has also been found as an essential part of the IκB kinase (IKK) complex required for the activation of NF-κB, perhaps by recruiting IκBα to the IKK complex (6). Alternative splicing of ERC1 generates 2 proteins with a divergent carboxy terminus, a long and a short form termed ERC1α and ERC1β, respectively. ERC1α is widely expressed, whereas ERC1β and a related family member ERC2 are expressed in the brain (4). Papillary thyroid carcinomas have been identified with the translocation t(10;12)(p11;p13) resulting in a fusion between ERC1 and the receptor tyrosine kinase Ret (1). |
| 存放说明 | -20C |
| 计算分子量 | 130, 120 |
参考图片Western blot analysis of extracts from HeLa (human), NIH/3T3 (mouse), NBT-II (rat) cell lines and from rat brain using ERC1 (P85) Antibody.Western免疫印迹。用ERC1 (P85) Antibody研究HeLa (人源), NIH/3T3 (小鼠源) 和NBT-II(大鼠源)细胞系的细胞提取液和大鼠脑提取液。 |
