| 货号 | 2061S |
| 反应种属 | Human/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | ENPP1 (L520) Antibody detects endogenous levels of total ENPP1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Ectonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) is a single-pass, type II transmembrane protein primarily involved in ATP hydrolysis at the plasma membrane. Targeting of ENPP1 to the basolateral cell surface relies on the presence of a carboxy-terminal di-leucine-based signal (1). ENPP1 plays important roles in bone mineralization and soft tissue calcification (2-5). Mutations in the corresponding ENPP1 gene cause generalized arterial calcification in infancy (GACI) and idiopathic infantile arterial calcification (IIAC) (6,7). ENPP1 inhibits insulin receptor function and overexpression of this enzyme causes insulin resistance and glucose intolerance in mice (8,9). Genetic variants of ENPP1 have been associated with obesity and type 2 diabetes (10-12). |
| 存放说明 | -20C |
| 计算分子量 | 140 kDa (Human), 110 kDa (Rodent) |
Western blot analysis of extracts from rat KNRK and human HepG2 cells using ENPP1 (L520) Antibody. 对大鼠KNRK和人HepG2细胞提液使用ENPP1 (L520) Antibody进行Western blot分析。 |
