DYRK2 Antibody
货号：
8143S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8143S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The DYRK family includes several dual-specificity tyrosine-phosphorylated and regulated kinases capable of phosphorylating proteins at both tyrosine and serine/threonine residues (1). The DYRK family was identified based on homology to the yeast Yak1 (2) and the Drosophila minibrain (mnb) kinases (3). Seven mammalian isoforms have been discovered, including DYRK1A, DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4, and DYRK4B. Differences in substrate specificity, expression, and subcellular localization are seen across the DYRK family (4,5). All DYRK proteins have a Tyr-X-Tyr motif in the catalytic domain activation loop, with phosphorylation of the second Tyr residue (e.g. Tyr312 of DYRK1A) necessary for kinase activity. DYRKs typically autophosphorylate the tyrosine residue within their activation loop, but phosphorylate substrates at serine and threonine residues (1,6).DYRK家族包括几个具有双重特异性酪氨酸磷酸化和调节的激酶，能够在酪氨酸和丝氨酸/苏氨酸残基处磷酸化多种蛋白(1)。DYRK家族的鉴定基于酵母Yak1 (2)和果蝇minibrain (mnb)激酶的同源性(3)。七个哺乳动物中的异构体已经被发现，包括DYRK1A，DYRK1B， DYRK1C，DYRK2，DYRK3，DYRK4和DYRK4B。DYRK家族的不同有底物特异性、表达水平和亚细胞定位(4,5)。所有的DYRK蛋白都具有一个Tyr-X-Tyr模体，位于催化结构域激活回路，第二个酪氨酸残基(如Tyr312 ，DYRK1A)的磷酸化对于激酶的活性是必不可少的。DYRKs典型的自体磷酸化其激活回路中的酪氨酸残基，而磷酸化底物时位于丝氨酸和苏氨酸残基处(1,6)。 |
| 存放说明 | -20C |
| 计算分子量 | 66, 60 |
参考图片Western blot analysis of extracts from various cell lines using DYRK2 Antibody.Western blot方法检测不同细胞提取物，使用的抗体为DYRK2 Antibody。 |
