DUSP10/MKP5 Antibody
货号：
3483S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3483S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | MAP kinases are inactivated by dual-specificity protein phosphatases known as MAPK phosphatases (MKP), that differ in their substrate specificity, tissue distribution, inducibility by extracellular stimuli and cellular localization. MKPs specifically dephosphorylate both threonine and tyrosine residues in MAPK P-loops and have been shown to play important roles in regulating the function of the MAPK family (1,2). At least 13 members of the family (MKP-1, PAC-1, VHR, MKP-2, HVH3, MKP-3, PYST2, HVH5, MKP-4, MKP-5, MKP-6, MKP-7, DSP2) display unique substrate specificities for various MAP kinases (3). MAPK phosphatases typically contain an amino-terminal rhodanese-fold responsible for MKP docking to MAPK family members and a carboxy-terminal catalytic domain (4). These phosphatases can play important roles in development, immune system function, stress responses and metabolic homeostasis (5), and also in the development of cancer and the response of cancer cells to chemotherapy (6). |
| 存放说明 | -20C |
| 计算分子量 | 54 |
参考图片Western blot analysis of extracts from RD and rat muscle cells using DUSP10/MKP5 Antibody. |
Western blot analysis of extracts from C2C12 cells, differentiated for the indicated time periods, using DUSP10/MKP5 Antibody. |
