| 货号 | 12243S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Drebrin A Antibody recognizes endogenous levels of total Drebrin A protein. This antibody does not cross-react with Drebrin E. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Developmentally-regulated brain proteins (Drebrins) are cytoplasmic proteins that were originally identified in the brain as F-actin-binding proteins. There are two mammalian isoforms: adult type (A) and embryonic type (E). These isoforms are derived from a single gene through alternative RNA splicing mechanisms (1). Drebrin E has been observed to accumulate in the developmental stage of migrating neurons and in the growing cell processes of neurons. Drebrin A is found at the dendritic spines of mature cortical neurons where it plays a role in synaptic plasticity (2,3). Although drebrins are primarily found in neurons, they have also been found in skeletal muscle, heart, pancreas, and kidney. Research studies have shown that reduced expression of drebrin in the brain could be associated with Alzheimer’s Disease, Down Syndrome (4), and bipolar disorders (5). |
| 存放说明 | -20C |
| 计算分子量 | 132 |
Western blot analysis of extracts from various cell lines using Drebrin A Antibody. Western blot 检测多种细胞系提取物，使用的抗体是Drebrin A Antibody兔多抗。 | |
Immunoprecipitation of Drebrin A from SH-SY5Y cell extracts, using Normal Rabbit IgG #2729 (lane 2) or Drebrin A Antibody (lane 3). Lane 1 is 10% input. Western blot analysis was performed using Drebrin A Antibody. 免疫沉淀方法检测SH-SY5Y细胞提取物中的Drebrin A，使用的抗体是Normal Rabbit IgG #2729 (泳道2)或Drebrin A Antibody兔多抗 (泳道3)。泳道1为10%对照。使用Drebrin A Antibody兔多抗进行Western blot分析。 |
