Drebrin (pan) Antibody
货号：
5052S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5052S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Developmentally-regulated brain proteins (Drebrins) are cytoplasmic proteins that were originally identified in the brain as F-actin-binding proteins. There are two mammalian isoforms: adult type (A) and embryonic type (E). These isoforms are derived from a single gene through alternative RNA splicing mechanisms (1). DrebrinE has been observed to accumulate in the developmental stage of migrating neurons and in the growing cell processes of neurons. DrebrinA is found at the dendritic spines of mature cortical neurons where it plays a role in synaptic plasticity (2,3). Although drebrins are primarily found in neurons, they have also been found in skeletal muscle, heart, pancreas, and kidney. Research studies have shown that reduced expression of drebrin in the brain could be associated with Alzheimer’s Disease, Down Syndrome (4), and bipolar disorders (5). |
| 存放说明 | -20C |
| 计算分子量 | 110-132 |
参考图片Western blot analysis of extracts from various cell lines and mouse and rat brain using Drebrin (pan) Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). Absence of detectable Drebrin expression in A-431 cells is expected. |
