| 货号 | 3696S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | DR5 Antibody detects the precursor and mature forms of isoforms 1 and 2 of DR5. Cross reactivity was not detected with other family members. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 背景 | The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems (1,2). The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases. |
| 存放说明 | -20C |
| 计算分子量 | 40, 48 |
Western blot analysis of extracts from HeLa cells either mock transfected or transfected with a DR5 cDNA, using DR5 Antibody. Western blot 检测HeLa细胞提取物，空质粒或DR5 cDNA转染，使用抗体为 DR5 Antibody。 | |
Western blot analysis of extracts from HT1080 and HepG2 cell lines, using DR5 Antibody. Western blot 检测HT1080和HepG2 细胞系提取物，使用抗体为 DR5 Antibody。 |
