| 货号 | 6447S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | DR1 Antibody recognizes endogenous levels of total DR1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Down-regulator of transcription 1 (DR1), also known as negative cofactor 2-β (NC2-β), forms a heterodimer with DR1 associated protein 1 (DRAP1)/NC2-α and acts as a negative regulator of RNA polymerase II and III (RNAPII and III) transcription (1-5). DR1 activity is thought to be important for modulating the switch between basal transcription activity and transcription activator driven transcription (2,6,7). DR1 interaction with TATA binding protein (TBP) blocks the association of general transcription factors TFIIA and TFIIB with TBP and disrupts the formation of the RNAPII transcription initiation complex (1,8,9). RNAPIII driven transcription is also inhibited by DR1 interaction with TBP. DR1 disrupts the interaction of TBP with the TFIIB related factor (BRF)/RNAPIII B-related factor, inhibiting transcription initiation by the RNAPIII machinery (4). |
| 存放说明 | -20C |
| 计算分子量 | 19 |
Western blot analysis of extracts from various cell lines using DR1 Antibody. 使用DR1 Antibody，免疫印迹(Western blot)分析不同细胞中DR1蛋白水平。 |
