DcR1 Antibody
货号：
4756S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4756S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | DcR1 Antibody detects endogenous levels of total DcR1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems (1,2). The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases. Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2 and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand (3-5). Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity (6-8). |
| 存放说明 | -20C |
| 计算分子量 | 28 |
参考图片Western blot analysis of extracts from Jurkat, Raji and A20 cell lines, using DcR1 Antibody. Western blot检测Jurkat、Raji和A20细胞系提取物，使用抗体为DcR1 Antibody。 |
