Cox2 Antibody
货号：
4842S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4842S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Cox2 Antibody detects endogenous levels of total Cox2 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Cyclooxygenase1 (Cox1) and cyclooxygenase2 (Cox2), family members with 60% homology in humans, catalyze prostaglandin production from arachidonic acid (1,2). While Cox1 expression is constitutive in most tissues, Cox2 expression is induced by lipopolysaccharide (LPS) and peptidoglycan (PGN) (3). PGN activates Ras, leading to phosphorylation of Raf at Ser338 and Erk1/2 at Tyr204. The activation of MAP kinase signaling results in subsequent activation of IKKα/β, phosphorylation of IκBα at Ser32/36, and NF-κB activation. Finally, activation of the transcription factor NF-κB is responsible for the induction of Cox2 expression (4). LPS and PGN induce the clinical manifestations of arthritis and bacterial infections, such as inflammation, fever, and septic shock (5), making Cox2 a useful target for therapeutic anti-inflammatory drugs (3). Cox1 and Cox2 also play a role in the neuropathology of Alzheimers disease by potentiating γ-secretase activity and β-amyloid generation (6). |
| 存放说明 | -20C |
| 计算分子量 | 74 |
参考图片Western blot analysis of extracts from Raw264.7 cells, untreated or LPS-treated (1 μg/ml for 6 h), using Cox2 Antibody.Western免疫印迹。用 Cox2 Antibody研究未经处理的和经LPS(1 μg/ml , 6 h) 处理的Raw264.7细胞的细胞提取液。 |
Western blot of extracts from Raw264.7 cells, untreated or LPS-treated (1 µg/ml for 6 h), using Cox2 Antibody.Western免疫印迹。用Cox2 Antibody研究未经处理的和经LPS(1 μg/ml , 6 h) 处理的Raw264.7细胞的细胞提取液。 |
