CNPase Antibody
货号：
2986S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2986S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | CNPase Antibody detects endogenous levels of total CNPase protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | CNPase (2, 3’-cyclic nucleotide 3-phosphodiesterase) catalyzes the in vitro hydrolysis of 2’, 3’-cyclic nucleotides to produce 2’-nucleotides. The in vivo molecular function and native substrate of this nucleotide phosphodiesterase remains under investigation (1). High CNPase expression is seen in oligodendrocytes and Schwann cells as CNPase accounts for roughly 4% of the total myelin protein in the central nervous system (2). CNPase binds to tubulin heterodimers and plays a role in tubulin polymerization, and oligodendrocyte process outgrowth (3). Typical myelination is seen in CNPase knock-out mice, but they suffer severe neurodegeneration from axonal loss and oligodendrocytes display abnormal paranodal loop structure prior to axonal degeneration. Paranodal loops typically contact the axolemma in axon-glial signaling; neurodegeneration in CNPase knock-out mice is a secondary consequence of impaired cell-cell communication (4). |
| 存放说明 | -20C |
| 计算分子量 | 47 |
参考图片Western blot analysis of extracts from mouse and rat brain using CNPase Antibody. Western blot分析大鼠和小鼠脑细胞提取物，使用的抗体是CNPase Antibody 兔多抗。 |
