| 货号 | 14181S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Mutations in Parkin or PINK1 cause recessively inherited Parkinson’s disease. In healthy mitochondria, PINK1 is rapidly degraded by mitochondrial proteases and the proteasome. Upon mitochondrial depolarization, PINK1 accumulates on the mitochondrial surface, recruits Parkin from the cytosol, and initiates mitophagy. The mitochondrial proteases MPP, PARL, m-AAA and CLPP have been implicated in PINK1 degradation and cleavage (3). |
| 存放说明 | -20C |
| 计算分子量 | 28 |
Western blot analysis of extracts from various cell lines using CLPP Antibody. | |
Immunoprecipitation of CLPP from A172 cell extracts using either Normal Rabbit IgG #2729 (lane 2) or CLPP Antibody (lane 3). Lane 1 is 10% input. Western blot analysis was performed using CLPP Antibody. | |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human CLPP protein (hCLPP-Myc/DDK; +), using CLPP Antibody. |
