CK2α Antibody
货号：
2656S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2656S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | CK2 (formerly called Casein Kinase II) is a highly conserved protein kinase with more than 300 substrates regulating cell growth, cell death, and cell survival. CK2 has been implicated in the response to UV irradiation-induced DNA damage, targeting XRCC1 (1) and BRCA1 (2) as well as regulating p53 tumor suppressor protein functions (3). Furthermore, CK2 plays a key role in NF-κB activation (4). UV irradiation stimulates CK2-mediated phosphorylation of several carboxy-terminal residues within IκBα, resulting in IκBα proteasomal degradation and the release and nuclear translocation of active NF-κB. CK2 is also dysregulated in many cancers (5) and neurodegenerative diseases such as Alzheimers and Parkinsons diseases (6). Structurally, CK2 is a multimeric protein complex consisting of two catalytic subunits (α or α) and two regulatory β subunits (7). CK2 is distributed ubiquitously and is apparently constitutively active (7). While cell cycle-dependent Ser-Pro phosphorylation sites have been identified on CK2α and CK2β, Tyr255 phosphorylation by the Src-related kinase c-Fgr seems to have the greatest effect on CK2α activity (8,9).CK2(以前称作酪蛋白激酶 II)是一种高度保守的具有300多个作用底物的蛋白激酶，能够调节细胞生长、细胞死亡和细胞存活。CK2在响应紫外照射诱导的DNA损伤中被发现，它能够靶向XRCC1 (1) 和BRCA1 (2)并能调节p53肿瘤抑制基因的功能(3)。此外，CK2在NF-κB的激活过程中发挥着关键的作用(4)。紫外照射能够刺激CK2介导的IκBα中几个羧基末端残基的磷酸化，引起IκBα的蛋白酶体降解和释放以及活化的NF-κB的核转移。CK2在许多肿瘤和神经退行性疾病如阿尔茨海默氏症和帕金森症中功能紊乱(6)。结构上讲，CK2是一个多聚化的蛋白复合体，由两个催化亚基(α or α)和两个调节亚基β组成(7)。CK2分布广泛，明显的组成活跃(7)。尽管CK2α 和CK2β上已鉴定出细胞周期依赖性的Ser-Pro磷酸化位点，Src-相关激酶 c-Fgr作用的255位酪氨酸磷酸化似乎对CK2α的活性有最大的影响(8,9)。 |
| 存放说明 | -20C |
| 计算分子量 | 42 |
参考图片Western blot analysis of lysates from various cell lines using CK2α Antibody.Western blot方法检测不同细胞提取物，使用的抗体为 CK2α Antibody。 |
