CK1ε Antibody
货号：
12448S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12448S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | CK1ε Antibody recognizes endogenous levels of total CK1ε protein. This antibody does not cross-react with CK1δ. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Casein Kinase I (CK1 or CKI) is the name given to a family of kinases consisting of multiple isoforms (α, α, β, γ1-3, δ, and ε) with a conserved N-terminal kinase domain and a variable C-terminal sequence that determines subcellular localization and regulates enzyme activity (1-3). Indeed, multiple inhibitory autophosphorylation sites have been identified near the C terminus of CK1ε (3). This ubiquitously expressed family of protein kinases has been implicated in multiple processes including DNA repair, cell morphology, and Wnt signaling (4). Perhaps the best understood role of CK1 is to provide the priming phosphorylation of β-catenin at Ser45 to produce the consensus GSK-3 substrate motif (S/T-X-X-X-pS) (4).CK1ε is involved in many cellular processes such as differentiation (5-7), cell growth and apoptosis (8), and control of the circadian rhythm (9,10). |
| 存放说明 | -20C |
| 计算分子量 | 43 |
参考图片 |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with constructs expressing Myc-tagged full-length human CK1δ (CK1δ-Myc/DDK; +) or Myc-tagged full-length human CK1ε (CK1ε-Myc/DDK; +), using CK1ε Antibody (upper) or Myc-Tag (71D10) Rabbit mAb #2278 (lower). |
