CK1 Antibody
货号：
2655S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2655S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | This antibody detects endogenous levels of total casein kinase I-alpha 1 protein. This antibody may cross-react with casein kinase I-epsilon, casein kinase I-delta, and casein kinase I-gamma. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | CK1 (Casein Kinase I or CKI) is the name given to a family of kinases consisting of multiple isoforms (alpha, alpha-prime, beta, gamma1-3, delta, and epsilon) with a conserved N-terminal kinase domain and a variable C-terminal sequence that determines subcellular localization and regulates enzyme activity (1-3). Indeed, multiple inhibitory autophosphorylation sites have been identified near the C-terminus of (CKI-epsilon) (3). This ubiquitously expressed family of protein kinases has been implicated in multiple processes including DNA repair, cell morphology, and Wnt signaling (4). Perhaps the best understood role of CKI is to provide the priming phosphorylation of beta-catenin at Ser45 to produce the consensus GSK-3 substrate motif (Ser/Thr-X-X-X-Phospho-Ser) (4). |
| 存放说明 | -20C |
| 计算分子量 | 34 |
参考图片Western blot analysis of lysates from various cell lines using Casein Kinase I Antibody.使用Casein Kinase I抗体对对多种细胞提取物进行western blot分析。 |
