CHD4 Antibody
货号：
4245S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4245S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | CHD4 Antibody detects endogenous levels of total CHD4 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Chromodomain-helicase-DNA-binding domain (CHD) proteins have been identified in a variety of organisms (1,2). This family of nine proteins is divided into three separate subfamilies: subfamily I (CHD1 and CHD2), subfamily II (CHD3 and CHD4), and subfamily III (CHD5, CHD6, CHD7, CHD8, CHD9). All CHD proteins contain two tandem amino-terminal chromodomains, a SWI/SNF-related ATPase domain, and a carboxy-terminal DNA binding domain (1,2). The chromodomains facilitate binding to methylated lysine residues of histone proteins and confer interactions with specific regions of chromatin. The SWI/SNF-related ATPase domain utilizes energy from ATP hydrolysis to modify chromatin structure. CHD proteins are often found in large, multi-protein complexes, with their transcriptional activation or repression activity governed by other proteins also found in the complex. CHD3 (also known as Mi2-α) and CHD4 (also known as Mi2-β) are central components of the nucleosome remodeling and histone deacetylase (NuRD) transcriptional repressor complex, which also contains HDAC1, HDAC2, RbAp48, RbAp46, MTA1, MTA2, MTA3, and MBD3 (3-8). Both CHD3 and CHD4 contain two PHD (plant homeodomain) zinc finger domains that bind directly to HDAC1 and HDAC2. |
| 存放说明 | -20C |
| 计算分子量 | 260 |
参考图片Western blot analysis of extracts from 293 and NCCIT cells using CHD4 Antibody. 使用CHD4 Antibody，免疫印迹(Western blot)分析293和NCCIT细胞中CHD4蛋白水平。 |
