CDC37 (V297) Antibody
货号：
3618S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3618S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | CDC37 is an important component of the HSP90 chaperone complex (1,2). It was initially identified for its involvement in cell-cycle progression and was later found to have a much broader role as a chaperone for a wide variety of kinases and other proteins (1-3). CDC37 protein has an amino-terminal kinase binding domain followed by a central HSP90 binding domain. It recruits and stabilizes kinases in the HSP90 complex by protecting the newly synthesized kinase peptide chain from degradation and promoting the next step of protein maturation (4,5). CDC37 also suppresses the ATPase activity of HSP90, thereby leading to conformational changes in the complex that preclude target kinase loading (6). CDC37 has been proposed as a therapeutic target because of its important role in multiple kinase pathways involved in proliferation and cancer cell survival, including Raf, Akt, Src, and ErbB2 pathways (7,8).CDC37是HSP90伴侣复合体的重要组成部分(1-3)。CDC37蛋白含有一个氨基末端激酶结合结构域紧随中央的HSP90结合结构域。它能够阻止新合成的激酶肽链被降解并促进蛋白成熟的下一个步骤从而招募和稳定HSP90复合体中的激酶(4,5)。CDC37也抑制HSP90的ATP酶活性，从而导致复合体的构象变化阻止靶激酶的进入(6)。由于CDC37在多激酶通路中的重要作用如增殖和肿瘤细胞存活包括Raf, Akt, Src和ErbB2通路(7,8)，它一直被认为是重要的治疗靶点。 |
| 存放说明 | -20C |
| 计算分子量 | 50 |
参考图片Western blot analysis of extracts from various cell lines using CDC37 (V297) Antibody.western blot方法检测不同细胞提取物，使用的抗体为CDC37 (V297) Antibody。 |
