| 货号 | 3351S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IF-IC |
| 目标/特异性 | CD79A Antibody detects endogenous levels of total CD79A protein. |
| 使用方法 | WB(1:1000) IF-IC (1:100) |
| 供应商 | CST |
| 背景 | Antigen receptors found on the surface of B-cells contain a hetrodimeric signaling component composed of CD79A and CD79B, also known as Ig α and Ig β, respectively (1,2). Presence of this receptor complex is essential for B-cell development and function (3). Together these two proteins and the associated B cell receptor initiate intracellular signaling following antigen binding (4,5). An immunoreceptor tyrosine-based activation motif (ITAM) is found in the CD79A intracellular region appears to be is important for its function (6). Antigen binding precedes formation of the CD79A and CD79B heterodimer and subsequent activation of receptor associated kinases (7). CD79A is a marker for B-lineage lymphoblastic leukemia (8); mutations in the corresponding mb-1 gene are responsible for abnormally low levels of functional B cell receptors in some cases of chronic B-cell lymphocytic leukemia (9). |
| 存放说明 | -20C |
| 计算分子量 | 45-55 |
Confocal immunofluorescent analysis of Ramos (left) and Jurkat cells (right) using CD79A Antibody (green). Blue pseudocolor= DRAQ5® #4084 (fluorescent DNA dye).共聚焦免疫荧光分析Ramos (左图) 和 Jurkat 细胞(右图) ，所用抗体为CD79A Antibody (绿色)。Blue pseudocolor= DRAQ5® #4084 ( DNA荧光染料 ) | |
Western blot analysis of extracts from Raji and Daudi cell lines using CD79A Antibody.Western免疫印迹。用CD79A Antibody研究Raji 和 Daudi细胞系的细胞提取液。 |
