| 货号 | 4915S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 目标/特异性 | CD54 (ICAM-1) Antibody detects endogenous levels of total CD54 protein. The antibody does not cross-react with other IgSF adhesion molecules. |
| 使用方法 | WB(1:1000) IHC-P (1:25) |
| 供应商 | CST |
| 背景 | Intercellular cell adhesion molecule-1 (CD54 or ICAM-1) is a cell surface glycoprotein that belongs to the immunoglobulin superfamily (IgSF) of adhesion molecules. CD54 is expressed at low levels in diverse cell types, and is induced by cytokines (TNF-α, interleukin-1) and bacterial lipopolysaccharide (1). Apical localization of CD54 on endothelial cells (or basolateral localization on epithelial cells) is a prerequisite for leukocyte trafficking through the endothelial (or epithelial) barrier (1). Apical expression of CD54 on epithelial cells mediates pathogen invasion as well as host defense, a pattern also observed in tumors (1). CD54 also functions as a co-stimulator on antigen presenting cells, binding to its receptor LFA-1 (leukocyte function-associated antigen-1) on the surface of T cells during antigen presentation (2). Cross-linking of CD54 or binding to its ligand triggers activation of Src family kinases and the Rho/ROCK pathway (3-7). Phosphorylation on Tyr485 of CD54 is required for its association with SHP-2 (5). SHP-2 seems essential for CD54-induced Src activation (7). |
| 存放说明 | -20C |
| 计算分子量 | 89, 92 |
Immunohistochemical analysis of paraffin-embedded human lymph node using CD54 (ICAM-1) Antibody in the presence of control peptide (left) or antigen specific peptide (right).在对照肽（左）货抗原特异性多肽（右）存在的条件下使用CD54（ICAM-1）抗体对石蜡包埋的人淋巴结组织进行免疫组化实验分析。 | |
Immunohistochemical analysis of paraffin-embedded Raji cells using CD54 (ICAM-1) Antibody.使用CD54（ICAM-1）抗体对石蜡包埋的淋巴瘤淋巴母细胞样细胞系进行免疫荧光分析。 |
