| 货号 | 8519S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Caspase-14 Antibody recognizes endogenous levels of total caspase-14 protein and the p11 subunit of mature caspase-14. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 背景 | Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression; it is found in embryonic tissues and adult skin (1,2). Caspase-14 is weakly processed into p18 and p11 subunits by caspase-8 (2). Caspase-14 may not play a role in apoptosis (2), but instead may regulate keratinocyte differentiation (3). Expression of caspase-14 may protect from psoriasis (4,5) and irradiation damage (6). Caspase-14 may also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes (6). |
| 存放说明 | -20C |
| 计算分子量 | 28-30, 11 |
Western blot analysis of extracts from mouse and rat skin using Caspase-14 Antibody. Western blot 检测小鼠和大鼠皮肤提取物，使用抗体为Caspase-14 Antibody。 | |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with an expression construct encoding human caspase-14 (hCaspase-14, +), using Caspase-14 Antibody. Western blot 方法检测293T细胞提取物：空质粒转染（-）或带编码人caspase-14 (hCaspase-14, +)转染；使用抗体为Caspase-14 Antibody。 |
