CARD9 Antibody
货号：
12416S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12416S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | CARD9 Antibody recognizes endogenous levels of total CARD9 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | CARD9 is a caspase recruitment domain (CARD)-containing adaptor protein expressed by myeloid cells (1,2). It is required for antifungal immunity downstream of pathogen detection by C-type lectin receptors (CLRs) such as Dectin-1 (3,4). Recognition of carbohydrates on fungal cell walls by CLRs leads to activation of the tyrosine kinase Syk, followed by activation of PKCδ (5,6). PKCδ phosphorylates CARD9, enabling the assembly of a complex containing CARD9 and Bcl10 (6). This complex activates NF-κB, resulting in upregulation of inflammatory cytokines important for initiation of adaptive immunity (3,4,6,7). CARD9 was also shown to be important for the induction of IL-1β, downstream of the viral nucleic acid sensor RIG-I, as well as for the generation of reactive oxygen species important for bacterial killing by macrophages (2,8). |
| 存放说明 | -20C |
| 计算分子量 | 62 |
参考图片Western blot analysis of extracts from THP-1, U-937, and MUTZ-3 cells using CARD9 Antibody.Western blot分析THP-1、U-937和 MUTZ-3细胞的细胞提取物，使用抗体是using CARD9 Antibody。 |
