CARD11 Antibody
货号：
4440S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4440S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | CARD11 Antibody detects endogenous levels of total CARD11 protein. Cross-reactivity was not detected with other family members at physiological conditions. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | CARD11/Carma1/Bimp3 belongs to the MAGUK (membrane-associated guanylate kinase) family that typically function as molecular scaffolds in the assembly of multiprotein complexes (1,2). MAGUK family members contain an SH3 domain, a PDZ domain and a GuK domain homologous to guanylate kinase. In addition, CARD11 contains an amino-terminal CARD domain (caspase recruitment domain). This domain plays an important role in forming interactions with a number of proteins containing CARD domains that are involved in regulating apoptosis and NF-κB activation. CARD11 is predominately expressed in lymphocytes (1,2) and associates with the CARD domain of Bcl10. When overexpressed, CARD11 leads to the phosphorylation of Bcl10 and activation of NF-κB (1,2). CARD11 is constitutively associated with lipid rafts and is thought to function by recruiting Bcl10 and MALT1 and triggering the phosphorylation of IKKs (3,4). Several studies using the genetic disruption of CARD11 or dominant-negative mutations have demonstrated that it plays a critical role in NF-κB activation and lymphocyte signaling (4-7). |
| 存放说明 | -20C |
| 计算分子量 | 130 |
参考图片Western blot analysis of extracts from Raji, Jurkat, Ramos and K562 cells, using CARD11 Antibody.Western免疫印迹。用CARD11 Antibody研究Raji, Jurkat, Ramos和K562 细胞的细胞提取液。 |
