CaMKI-δ Antibody
货号：
3365S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3365S |
| 反应种属 | Human/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | CamKI-δ Antibody detects endogenous levels of total CamKI-δ protein. This antibody may detect other isoforms of CamKI. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The Ca2+/calmodulin-dependent kinase (CaMK) family, which is activated in response to elevation of intracellular Ca2+, includes CaMKI, CaMKII, CaMKIV and CaMK-kinases (CaMKKs) (1,2). CaMKI is a downstream substrate of CaMKK and has 4 isoforms: CaMKI-α, CaMKI-β, CaMKI-γ and CaMKI-δ. CaMKI is present in most cell types and may be involved in cellular functions including transcription, cytoskeletal organization, axonal growth cone motility and long-term potentiation in neurons (3-6). CaMKII is also ubiquitously expressed in most cell types. While muscular CaMKII has been linked to activation of mitochondrial biogenesis in muscle hypertrophy response, neuronal CaMKII regulates important neuronal functions, including neurotransmitter synthesis, neurotransmitter release, modulation of ion channel activity, cellular transport, cell morphology and neurite extension, synaptic plasticity, learning and memory and gene expression (7). Like CaMKI, CaMKIV is also a substrate of CaMKKs and is primarily restricted to the nucleus of neurons. CaMKIV regulates gene transcription in neurons through phosphorylation of transcription factors such as CREB and is required for fear memory (8).CamKI-δ translocates to the nucleus upon intracellular Ca2+ influx and is activated through phosphorylation of Thr180 by CamKK (9). |
| 存放说明 | -20C |
| 计算分子量 | 43 |
参考图片Western blot analysis of extracts from HeLa cells, transfected with a construct overexpressing CaMKI-δ, and rat skeletal muscle using CaMKI-δ Antibody. Western blot分析转染过表达CaMKI-δ载体的HeLa细胞和大鼠骨骼肌提取物，使用的抗体是CaMKI-δ Antibody 兔多抗。 |
