| 货号 | 4032S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | CaMKIV Antibody detects total levels of endogenous CaMKIV. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | CaMKIV is an important member of calcium/calmodulin-activated kinases. CaMKIV signaling has been related to long-term neural potentiation and memory (1,2), as well as T-cell receptor signaling (3). CaMKIV has catalytic and regulatory domains. The Ca2+/calmodulin-dependent CaMKK phosphorylates CaMKIV, releasing the autoinhibitory effect and thus activating the kinase (4-6). The activated CaMKIV further autophosphorylates itself at Thr196 (or Thr200 in human) to render the kinase constitutively active (5). The threonine phosphorylation state of CaMKIV can be downregulated by PP2A dephospho rylation. |
| 存放说明 | -20C |
| 计算分子量 | 58, 60: human. 61, 63: rat and mouse. |
Western blot analysis of extracts from human Jurkat cells (lane1), rat brain (lane 2) and mouse brain (lane 3), using CaMKIV Antibody. Western blot分析人Jurkat细胞（列1）、大鼠脑（列2）和小鼠脑（列3）提取物，使用的抗体是CaMKIV Antibody 兔多抗。 |
