Caldesmon-1 Antibody
货号：
2980S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2980S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Caldesmon-1 is an actin filament stabilizing protein involved in the regulation of cell contraction. Binding of caldesmon to actin is weakened by phosphorylation and by calmodulin in the presence of calcium. Caldesmon-1 is encoded by a single gene, which is spliced to generate a widely distributed low molecular weight form and a smooth muscle specific high molecular weight form (1,2). Caldesmon-1 is phosphorylated by the cyclin dependent kinase cdc2 and Erk1/2 MAP kinase, both of which prevent the activity of caldesmon-1 (3-5). Phosphorylation of caldesmon by cdc2 is required for passage of cells through mitosis (6). Phosphorylation by Erk1/2 is important in regulating smooth muscle contraction (7). Caldesmon-1 activity may play a role in the formation of podosomes, adhesion complexes associated with the secretion of matrix metalloproteases, invasion and metastasis (reviewed in 5).Caldesmon-1蛋白是一个肌动蛋白丝稳定蛋白，其涉及到细胞收缩的调节。caldesmon与actin的结合力通过磷酸化和钙离子存在的钙调蛋白是减弱。 Caldesmon-1蛋白是通过一个单个基因编码的，其被剪切成一个广泛分布低分子量的形式和一个平滑肌特异性的高分子量的形式(1,2)。Caldesmon-1 蛋白通过细胞周期蛋白依赖性激酶 cdc2和Erk1/2 MAP激酶磷酸化，这两个激酶都能抑制caldesmon-1蛋白的活性(3-5)。caldesmon蛋白通过cdc2激酶的磷酸化对于细胞进入有丝分裂的通路是需要的(6)。通过Erk1/2激酶磷酸化在调节平滑肌收缩中有着重要作用(7)。Caldesmon-1蛋白活性可能在伪足的形成、与基质金属蛋白酶的分泌有关粘附复合物和侵袭转移扮演重要角色（5）。 |
| 存放说明 | -20C |
| 计算分子量 | 70-80 non-muscle, 120-150 smooth muscle |
参考图片Western blot analysis of extracts from various cell types using Caldesmon-1 Antibody.使用Caldesmon-1 Antibody，免疫印迹（Western Blot）分析不同细胞系Caldesmon-1蛋白水平。 |
